The author, E.B.White, wrote Stuart Little in 1945, seven years before his most famous book, Charlotte's Web. With this in mind, there will obviously be vocabulary words that students (and maybe adults) need explained. What a great learning opportunity! (I confess, I'm a vocabulary nerd and love that kind of lesson.)
Here are a few of the words we have come across while we've read...shinnying, handkerchief, inquire, horrified, violet water, worsted suit, washbasin, and seize. Depending on the age of your reader you can modify your list to what needs to be defined and what can be figured out with the context clues provided in the sentences around the word.
One of our favorite activities that we did during chapter II was to read "Three Blind Mice" and talk about other old nursery rhymes. One of my most loved memories of spending time with my own mother was listening to and reciting old nursery rhymes. If you are a little rusty on these, let me know and I'll check out one of our great nursery rhyme books for you. How has your family been enjoying our book?